"Comparative clinical study between Ropivacaine and Ropivacaine with Dexmedetomidine in Epidural Anesthesia for Abdominal Hysterectomy"

Background: Many techniques and drug have been tried from time to time to calm the patients and eliminate the anxiety component during regional anesthesia. Ropivacaine is a good agent for use in epidural anesthesia but having side effects like neurotoxicity and cardiac toxicity. Aims: This present study is designed to evaluate effects of epidural ropivacaine 0.75% and ropivacaine 0.75% with dexmedetomidine on the patients undergoing elective abdominal hysterectomy. Settings and Design: Randomized, prospective and comparative study Methods and Material : In this study, patients were randomly allocated into two groups of 30 each. Group I(R) received epidural Ropivacaine 0.75 % (17 ml) (127.5 mg) and Group II(RD) received epidural Ropivacaine 0.75 % (17 ml) (127.5 mg) with dexmedetomidine 1.5 ug/kg. Sensory, motor and hemodynamic profile between two groups was compared. Statistical Analysis: Mean and standard deviation was calculated. Test of analysis between 2 groups was done by„t‟ test and chi square test then P value was calculated. Results and Conclusion: No significant difference was found between the groups in sensory and motor profile.( P<0.05). Hemodynamic stability was found better with dexmedetomidine. Rescue analgesic requirement was reduced in dexmedetomidine group.